Human development XVIII: A theory for immune system regulation (the “self-nonself discrimination”)
نویسندگان
چکیده
Tyge Dahl Hermansen, Søren Ventegodt, Isack Kandel and Joav Merrick Quality of Life Research Center, Classensgade 11C, 1 sal, DK-2100 Copenhagen O, Denmark Research Clinic for Holistic Medicine and Nordic School of Holistic Medicine, Copenhagen, Denmark; Scandinavian Foundation for Holistic Medicine, Sandvika, Norway; Interuniversity College, Graz, Austria; 6 Faculty of Social Sciences, Department of Behavioral Sciences, Ariel University Center of Samaria, Ariel, Israel; National Institute of Child Health and Human Development, Office of the Medical Director, Division for Mental Retardation, Ministry of Social Affairs, Jerusalem, Israel and Kentucky Children’s Hospital, University of Kentucky, Lexington, United States
منابع مشابه
An identical mechanism governs self-nonself discrimination and effector class regulation
Prevailing immunological dogma dictates self-nonself discrimination, meaning to respond or not, and effector class regulation, meaning choosing the most effective response, are two separate decisions the immune system makes when faced with a new antigen. Representing a cardinal departure from the past, our model instead predicts both self-nonself discrimination and effector class regulation are...
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The destructive effector functions of the immune system pose a problem that has aptly been described as 'horror autotoxicus'. This problem demands a solution that offers an effective self-nonself discrimination mechanism. Unlike all other defence mechanisms, the immune system makes the self-nonself discrimination somatically, and not at the germline level. This discrimination requires a way of ...
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